Promethazine is a first-generation antihistamine of the phenothiazine family. The drug has anti-motion sickness, antiemetic, and anticholinergic effects, as well as a strong sedative effect and in some countries is prescribed for insomnia when benzodiazepines are contraindicated. It is available over-the-counter in the United Kingdom, Australia, Switzerland, and many other countries, but by prescription in the United States. Brand names for promethazine include, in alphabetical order: Atosil, Avomine, Fargan, Farganesse, Lergigan, Phenergan, Promethegan, Prothiazine, Receptozine, Romergan and Sominex in the UK.
Some common side effects include:
- Tardive dyskinesia
- Confusion in the elderly
- Drowsiness, dizziness, fatigue, more rarely vertigo
- Dry mouth
- Respiratory depression in patients under age of 2 and in those with severely compromised pulmonal function
- Chest discomfort/pressure (typically in cases when patient is already taking medication for high blood pressure)
- Euphoria (very rare, except with high IV doses and/or coadministration with opioids/CNS depressants)
- Short temper/irritability
Extremely rare side effects include:
- Neuroleptic malignant syndrome (NMS)
Because of potential for more severe side effects, this drug is on the list to avoid in the elderly. (See NCQA’s HEDIS Measure: Use of High Risk Medications in the Elderly.)
- PHENERGAN (promethazine)
- 240 comp. at 25 mg.
- Without prescription.
Mechanism of action
You'll fall asleep and die silently. The probability of death depends on how fast you can be treated.
In many countries worldwide, you can legally buy Phenergan (promethazine) without a prescription.
- Option #1:
|Antiemetic drugs must be taken beforehand|
|Template:Interwiki (Base)||6 grams|
- Option #2:
The "Lytic Cocktail" (Phénergan, Largactil and Dolosal) used in France for euthanasia.
- "Suicide mode d'emploi" (p. 182)
- EXA : A guide to self-deliverance. Exit England, june 1981.
- How to die with dignity, by George B. Mair. Exit Écosse, s;d; (sept. 1980)
- Faut-il légaliser l’euthanasie ?