Radiation Oncology/Prostate/Workup

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Front Page: Radiation Oncology | RTOG Trials | Randomized Trials

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Prostate: Main Page | Prostate Overview | Screening and Prevention | Workup | Natural History | External Beam RT | IMRT | Androgen Suppression Therapy | Brachytherapy | Protons | Prostatectomy | Adjuvant RT after Prostatectomy | Salvage RT | Chemotherapy | Localized prostate cancer | Node Positive | Advanced disease | Recurrence after RT | Cryotherapy | RTOG Prostate Trials | Randomized Evidence

[edit] Screening

  • VA, 2006 - PMID 16401808 — "The effectiveness of screening for prostate cancer: a nested case-control study." Concato J et al. Arch Intern Med. 2006 Jan 9;166(1):38-43.
    • Case control study. 71,000 men in 10 VA hospitals. 501 pts dx with prostate cancer between 1991-95 and died by 1999. Compared with controls.
      • No difference in rate of a screening PSA +/- DRE between cases (14%) and controls (13%)
    • Conclusion: screen does not reduce mortality


[edit] Bone Metastases Detection

  • Brussels, 2007 (Belgium) PMID 17664475 -- "Magnetic resonance imaging of the axial skeleton for detecting bone metastases in patients with high-risk prostate cancer: diagnostic and cost-effectiveness and comparison with current detection strategies." (Lecouvet FE, J Clin Oncol. 2007 Aug 1;25(22):3281-7.)
    • Prospective. 66 patients with high-risk PCA (newly diagnosed PCA with GS >=8 and PSA >=20; PSA recurrence after RP with PSADT <12 months; on ADT and PSADT <12 months). Evaluated by bone scan + targetedplain films (BS/TXR) vs. bone scan + targeted plain films + MRI-on request (BS/TXR/MRIor) vs. axial MRI (MRIas)
    • Outcome: 62% bone mets. MRIas more sensitive than current sequence of sequential workup (bone scan, targeted XR, MRI of area at risk)
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