Radiation Oncology/NHL/Cutaneous

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Front Page: Radiation Oncology | RTOG Trials | Randomized Trials

Non-Hodgkin lymphoma: Main Page | Randomized
Overview: Overview | Follicular | Diffuse large B-cell | MALT | Nodal marginal zone | Mantle cell | CLL/SLL | Lymphoblastic | Burkitt | NK/T cell | Anaplastic large cell | Primary CNS Lymphoma
Treatment: Aggressive | Specific sites | Radioimmunotherapy

Cutaneous Lymphoma

  • Liao et al. 2010 (PMID: 20586627) Clinicopathologic analysis of cutaneous lymphoma in taiwan: a high frequency of extranodal natural killer/t-cell lymphoma, nasal type, with an extremely poor prognosis (Arch Pathol Lab Med. 2010 Jul.): (1) A total of 56 patients with cutaneous lymphomas were retrospectively collected and were reclassified according to the 2005 World Health Organization and the European Organization for Research and Treatment of Cancer and the 2008 World Health Organization classifications (2) Thirty-one (55%) tumors were primary cutaneous lymphomas, and twenty-five (45%) tumors were secondary or concurrent cutaneous lymphomas (3) Among primary cutaneous lymphomas, 23 cases (74%) were T-cell or natural killer-cell lymphomas, and 8 cases (26%) were B-cell lymphomas (extranodal natural killer/T-cell lymphoma, nasal type, and primary cutaneous peripheral T-cell lymphoma, unspecified) Conclusion: Compared with the Western countries, there was a higher frequency of extranodal natural killer/T-cell lymphoma, nasal type, and a lower frequency of mycosis fungoides in Taiwan.
  • WHO; 2008 PMID 15692063 -- "WHO-EORTC classification for cutaneous lymphomas." (Willemze R, Blood. 2005 May 15;105(10):3768-85.)
    • Classification system for primary cutaneous lymphomas

Histology Frequency 5-year DSS Clinical Course
T-cell cutaneous lymphomas
Mycosis fungoides 44% 88% Indolent
Variants of MF <5% 80-100% Indolent
Sezary syndrome 3% 24% Aggressive
Primary cutaneous anaplastic large cell lymphoma (CD30+) 8% 95% Indolent
Lymphomatoid papulosis (CD30+) 12% 100% Indolent
Subcutaneous panniculitis-like T-cell lymphoma 1% 82% Indolent
Extranodal NK/T-cell lymphoma, nasal type <1% -- Aggressive
Primary cutaneous T-cell lymphoma, unspecified 2% 16% Aggressive
B-cell cutaneous lymphomas
Primary cutaneous marginal zone B-cell lymphoma 7% 99% Indolent
Primary cutaneous follicle center lymphoma 11% 95% Indolent
Primary cutaneous diffuse large B-cell lymphoma, leg type 4% 55% Intermediate
Primary cutaneous diffuse large B-cell lymphoma, other <1% 50% Intermediate