Leiomyosarcoma: Main Page
Current staging 
AJCC 7th Edition (2009)
- Corresponds to updated FIGO staging (2009)
- FIGO 2009 PMID 19345353 -- "Revised FIGO staging for carcinoma of the endometrium."
- This staging now applies only to endometrial carcinomas and there is now a separate staging for uterine sarcomas.
- Carcinosarcomas (MMMT) should be staged as high grade carcinoma.
Primary Tumor: (FIGO Stage in parentheses)
- Note: FIGO uses pathologic staging
- Tis - in situ
- Note: FIGO no longer includes Stage 0
- T1 (I) - confined to corpus
- T1a (IA) - limited to endometrium or invades less than 1/2 of myometrium
- T1b (IB) - invades ≥ 1/2 of myometrium
- T2 (II) - invades stromal tissue of the cervix but does not extend beyond uterus
- Note: endocervical glandular involvement only should be considered as Stage I not Stage II
- T3a (IIIA) - involves serosa and/or adnexa (direct extension or metastasis)
- T3b (IIIB) - vaginal involvement (direct extension or metastasis) or parametrial involvement
- T4 (IVA) - invades bladder mucosa and/or bowel mucosa
Regional Lymph Nodes:
- N0 - none
- N1 (IIIC1) - metastasis to pelvic lymph nodes
- N2 (IIIC2) - metastasis to para-aortic lymph nodes
- Note: Regional nodes include obturator, internal iliac, external iliac, common iliac, para-aortic, presacral, and parametrial
- Note: For pathologic staging, FIGO classifies cases with <6 resected LNs as pNX
- M0 - none
- M1 (IVB) - distant metastasis - includes inguinal LN, intraperitoneal disease, lung, liver, or bone.
- Corresponds to FIGO stage given above (in parentheses)
Changes from 6th Edition:
- No longer includes uterine sarcoma (now staged with a new staging system)
- Positive peritoneal cytology is no longer considered (previously was T3a/IIIA)
- Involvement of the endocervical glands is not longer considered (previously was Stage IIA)
- Stages IA+IB combined (now: IA). IC moved to IB.
- Stage IIIC subdivided into IIIC1 and IIIC2.
Older staging systems 
FIGO moved to surgical staging in 1988 (AJCC 6th edition same). There is also a clinical staging system developed by FIGO in 1971.
Note: until the update of the FIGO / AJCC in 2009, uterine sarcomas and carcinomas were staged using the same system
AJCC 6th Edition (2002)
- IA - Limited to endometrium
- IB - < 1/2 of myometrium
- IC - 1/2 or more of myometrium
- II - invades cervix
- IIA - glandular epithelium of endocervix
- IIB - stroma of cervix
- III - extra-uterine
- IIIA - involves serosa and/or adnexa (direct extension or mets) and/or ascites or positive peritoneal washings
- IIIB - vaginal involvement (direct extension or mets)
- IIIC - LN+ (pelvic and/or paraaortic)
- IV - other organs
- IVA - bladder or bowel
- IVB - distant mets
Clinical staging 
Staging is now surgical (see above), but clinical staging may be utilized for non-operative pts.
- I - Confined to corpus
- IA - Length of uterine cavity 8 cm or less
- IB - Length of uterine cavity > 8 cm
- II - Involves corpus and cervix, but no extension beyond the uterus
- III - Extends outside uterus but not outside true pelvis
- IV - Outside the true pelvis or involves bladder or rectum
- IVA - Involves bladder, rectum, sigmoid, or small bowel
- IVB - Distant mets
Stage distribution 
|Stage||US SEER (PMID 16977653)||FIGO (PMID 17161155)|