Radiation Oncology/Bladder/Randomized

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Bladder Cancer Level I Evidence

In the process of being cross-linked ...


  • MRC T1 Bladder (1991-2003)
    • Randomized, 2 strata. 210 patients with pT1G3 TCC
      • Unifocal disease & no Tis: Arm 1) observation vs. Arm 2) RT 60/30
      • Multifocal disease and/or Tis: Arm 1) intravesical therapy (MMC or BCG) vs. Arm 2) RT 60/30
    • 2007 PMID 17631326 -- "A randomized trial of radical radiotherapy for the management of pT1G3 NXM0 transitional cell carcinoma of the bladder." (Harland SJ, J Urol. 2007 Sep;178(3 Pt 1):807-13; discussion 813. Epub 2007 Jul 16.)
      • Outcome: No difference in PFS, OS, or cystectomy rate
      • Conclusion: No evidence that RT is better than mor conservative treatment; prognosis poor regardless
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