The Zebrafish in Toxicology/Granulosa cells

From Wikibooks, open books for an open world
Jump to navigation Jump to search

Reproduction - Ovary[edit | edit source]

Normal Histology[edit | edit source]

Granulosa cells[edit | edit source]

Oocytes are lined by two layers, an internal granulosa cell layer and an external theca layer.

The granulosa cell layer develops gradually with the growing oocyte. Early previtellogenic oocytes are accompanied by flat epithelial granulosa cells [red arrowhead], granulosa cells with larger oocytes [blue arrowheads] have a higher appearance.

The theca cell layer is composed of stroma cells [green arrowheads] and contains capillaries [c]. The theca layer is continuous [black arrowheads] over neighbouring oocytes.

Note radial striation in the zona radiata [zr] of large vitellogenic oocytes.

Adult female zebrafish, H&E staining