Radiation Oncology/Sarcoma/Hemangioendothelioma

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  • Rare tumor
  • Intermediate-grade malignant tumors, clinically behaving between benign hemangioma and malignant angiosarcoma. Some have rather benign course while others show much more malignant progression
  • Typically occur in adults with roughly equal sex distribution
  • Most common location is soft tissues, but have been described essentially anywhere in the body
  • Symptoms depend upon location of the primary tumor
  • Most common histologic type is epithelioid hmangioendothelioma (EHE)
  • For isolated tumors, curative resection with negative margin should be performed
  • Role of adjuvant RT is unclear, but is often considered
  • Most common metastatic sites are lungs, liver, lymph nodes and bone
  • Effectiveness of chemotherapy is unclear
  • Most studies are small single institution series