Radiation Oncology/Liver/HCC/Protons

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Proton Therapy for Hepatocellular Carcinoma

  • Loma Linda; 2004 PMID 15508084 -- "High-dose proton beam radiotherapy of hepatocellular carcinoma: preliminary results of a phase II trial." (Bush DA, Gastroenterology. 2004 Nov;127(5 Suppl 1):S189-93.)
    • Phase II. 34 patients, unresectable HCC, T1-4N0M0. Child-Pugh score <=10. Average tumor size 5.7 cm. PT 63 CGE/15 over 3 weeks. Median F/U 1.7
    • Outcome: 2-year LC 75%, OS 55%. Declining AFP 85%. 6 liver transplant, 2 no residual HCC
    • Toxicity: small decrease in albumin and increase in bilirubin, 3 duodenal/colonic bleeding
    • Conclusion: Majority responded to treatment, and it was well tolerated.