Radiation Oncology/Cancer Syndromes/Ataxia-Telangiectasia-Like Disorder

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Ataxia-Telangiectasia-Like Disorder

  • Mutation in MRE11 (part of MRN complex)
  • Critical in recognition and repair of DNA double strand breaks
  • Cells are radiosensitive
  • Similar clinical features as Ataxia-Telangiectasia

  • Birmingham, UK; 2004 PMID 15279810 -- "Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis."(Taylor AM, DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1219-25.)
    • Review