Ossicle/Oncology

From Wikibooks, open books for an open world
< Ossicle
Jump to navigation Jump to search

Head and Neck Oncologic Surgery[edit]

THYROID DISEASE[edit]

Medullary Thyroid Carcinoma produces calcitonin

    • Amyloid and leukocytic infiltrate on path
    • Associated with RET-protooncogene and MEN IIa and IIb


Thyroid Binding Globulin

    • Increases with estrogens, BCP's, pregnanacy
    • Decreases with androgens
    • High TBG = High T4, Low T3RU (T3RU inversely proportional to # unoccupied T3 binding sites)
    • High T3RU with hyperthyroidism, alternate ligands - salicylate, clofibrate
    • Low T3RU with hypothyroidism, increased TBG


T1 + T1 => T2, PLUS ADD'L T2 => T4 => T3 + T1

    • T4 => T3 blocked in periphery by propylthiouracil
    • Tyr => Iodotyrosine blocked by thiouracil
    • T3 much more active than T4, half life 30h
    • T4 less active, half life 7 days
    • Serum T4 = Bound + Free (free T4 is active)


Hypothyroidism - Low T4, Low T3RU

Hyperthyroidism - High T4, High T3RU

Grave's Ophthalmopathy - decompress orbits into ethmoids and maxillary sinus

Thyroiditis

    • Acute Suppurative - (rare), hi WBC, nl ESR; Staph, Strep, Pneumococcus
    • Subacute (DeQuervan's) - (common), Decr T3RU, High T3 & T4; Rx steroids, ASA
    • Fibrous (Reidel's) - (rare), Rx debulking, steroids, cyclophosphamide
    • Chronic Lymphocytic (Hashimoto's) - (common), α-microsomal and α-TBG antibodies; Rx: thyroxine
    • Chronic non-suppurative - (rare)