Handbook of Genetic Counseling/FISH

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FISH is a technique where you can identify minor changes in chromosomes with the help of fluorescent dyes called probes. These probes are highly sensitive to light. They bind with the specified target and emit signals under the fluorescent microscope and minor deletions and inversions translocations can be identified. This is widely used for prenatal diagnosis and preimplantation genetic diagnosis in identification of trisomies and other structural and numerical abnormalities.Each chromosomes has its own probe.