Gynecologic Oncology/Cervical Cancer

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Chemotherapy for advanced and recurrent disease[edit]

  • Bonomi et al (GOG 43) PMID 3894589
    • Compared three regimens of cisplatin dosing
      • Regimen 1: 50 mg/m2 every 21 days
      • Regimen 2: 100 mg/m2 every 21 days
      • Regimen 3: 20 mg/m2 for five consecutive days repeated every 21 days
    • Differences in overall response rates were higher for regimen 2 (SS), but the PFS/OS/Complete response rates were virtually identical (NS)
    • Established 50 mg/m2 as the preferred regimen due to lower toxicity and ease (regimen 3 had multiple hospital visits)
Regimen Number PFS OS Response Rate (RR)
1 150 3.7 7.1 20.7%
2 166 4.6 7 31.4%
3 128 3.9 6.1 25 %