Chemical Sciences: A Manual for CSIR-UGC National Eligibility Test for Lectureship and JRF/Membrane introduction mass spectrometry

From Wikibooks, open books for an open world
Jump to navigation Jump to search

Membrane introduction mass spectrometry (MIMS) is a method of introducing analytes into the mass spectrometer's vacuum chamber via a semipermeable membrane.[1][2] Usually a thin, gas permeable, hydrophobic membrane is used, for example polydimethylsiloxane. Samples can be almost any fluid including water, air or sometimes even solvents. The great advantage of the method of sample introduction is its simplicity. MIMS can be used to measure a variety of analytes in real-time, with little or no sample preparation. MIMS is most useful for the measurement of small, non-polar molecules, since molecules of this type have a greater affinity for the membrane material than the sample.


  1. Johnson RC, Cooks RG, Allen TM, Cisper ME, Hemberger PH (2000). "Membrane introduction mass spectrometry: trends and applications". Mass spectrometry reviews 19 (1): 1–37. doi:10.1002/(SICI)1098-2787(2000)19:1<1::AID-MAS1>3.0.CO;2-Y. PMID 10715830. 
  2. Demeestere K, Dewulf J, De Witte B, Van Langenhove H (2007). "Sample preparation for the analysis of volatile organic compounds in air and water matrices". Journal of chromatography. A 1153 (1-2): 130–44. doi:10.1016/j.chroma.2007.01.012. PMID 17258752.