Chemical Sciences: A Manual for CSIR-UGC National Eligibility Test for Lectureship and JRF/High-field asymmetric waveform ion mobility spectrometry

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High-field asymmetric waveform ion mobility spectrometry (FAIMS or RF-DC ion mobility spectrometry) is a mass spectrometry technique in which ions at atmospheric pressure are separated by the application of a high-voltage asymmetric waveform at radio frequency (RF) combined with a static (DC) waveform applied between two electrodes.[1][2] Depending on the ratio of the high-field and low-field mobility of the ion, it will migrate toward one or the other electrode. Only ions with specific mobility will pass through the device.


  1. Guevremont R (November 2004). "High-field asymmetric waveform ion mobility spectrometry: a new tool for mass spectrometry". J Chromatogr A 1058 (1-2): 3–19. PMID 15595648. 
  2. Kolakowski BM, Mester Z (September 2007). "Review of applications of high-field asymmetric waveform ion mobility spectrometry (FAIMS) and differential mobility spectrometry (DMS)". Analyst 132 (9): 842–64. doi:10.1039/b706039d. PMID 17710259.