Biochemistry/Gluconeogenesis

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The process named gluconeogenesis allows cell to gain glucose from noncarbohydrate sources. However, this process should not be considered as just opposite of glycolysis. It bypasses irreversible reactions of glycolysis, but the remaining reaction happens just as opposite direction of glycolysis. Thus, it will be better to investigate only irreversible steps of gluconeogenesis.

Overview[edit | edit source]

Gluconeogenese.png

Irreversible steps of gluconeogenesis[edit | edit source]

Step 1[edit | edit source]

First rate limiting step of gluconeogenesis

Step 7[edit | edit source]

Reaction goes to F6P side is one of the part of gluconeogenesis and catalyzed by FBPase-1

Step 10[edit | edit source]

Reaction goes to glucose side is the last step of gluconeogenesis and catalyzed by glucose 6-phosphatase

References[edit | edit source]

  • Nelson, D. L., & Cox, M. M. (2008). Glycolysis, gluconeogenesis, and the pentose phosphate pathway. Lehninger Principles of Biochemistry, 4, 521-559.
  • Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. Chapter 16, Glycolysis and Gluconeogenesis.