A-level Chemistry/OCR (Salters)/Nitrile hydrolysis
Nitrile hydrolysis proceeds by the mechanism outlined below. It begins with protonation of the nitrile nitrogen, which increases the partial positive charge on carbon and therefore renders carbon more susceptible to nucleophilic attack by a water molecule. Addition of water to the nitrile is the key step in nitrile hydrolysis − the next few steps are simple proton transfers, until an amide is formed. The amide then typically undegoes further hydrolysis to a carboxylic acid.