Radiation Oncology/Cancer genetics

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List of Chromosomes and their related cancer genes[edit]

Chromosome 1

Chromosome 2

Chromosome 3

  • 3p26: Von-Hippel Lindau, VHL gene (3p26)

Chromosome 4

Chromosome 5

  • 5q deletion: Familial Adenomatous Polyposis (FAP) Syndrome and Hereditary Colorectal Syndromes

Chromosome 6

Chromosome 7

Chromosome 8

Chromosome 9

  • 9q34.1: Abl, involved in bcr-abl fusion gene
  • 9q34: TSC1, involved in tuberous sclerosis

Chromosome 10

Chromosome 11 ATM is located on human chromosome 11 (11q22.3) Chromosome 12

Chromosome 13

  • 13q15: Rb, retinoblastoma, other tumors

Chromosome 14

Chromosome 15

Chromosome 16

  • 16p13: TSC2, involved in tuberous sclerosis

Chromosome 17

  • 17p13.1: p53 (TP53) tumor suppressor

Chromosome 18

  • 18q21.3: Bcl-2 gene, follicular lymphoma, t(14;18)(q32;q21)

Chromosome 19

Chromosome 20

Chromosome 21

Chromosome 22

  • 22q11.2: Bcr gene, bcr-abl translocation (Philadelphia chromosome), CML
  • 22: EWS gene, Ewing's sarcoma

Chromosome X

Chromosome Y

Chromosomal translocations involved in oncology[edit]

See also List of chromosomal translocations at Wikipedia
  • t(1;12)(q21;p13)
    • Acute myelogenous leukemia
  • t(1;13)
  • t(2;5)(p23;q35)
    • Anaplastic large cell lymphoma
  • t(2;13)
  • t(8;14)
    • c-myc
    • Burkitt's lymphoma
  • t(9;12)(p24;p13) CML, ALL
  • t(9;22)(q34;q11)
    • BCR-ABL (Philadelphia chromosome). Role of BCR is not completely clear, but appears to be involved with superoxide production. Abl has 2 isoforms: nuclear abl is involved with regulation of cell death after DNA damage. Cytoplasmic abl appears to function in cell adhesion
    • Results in CML, ALL
  • t(11;14)
    • Mantle cell lymphoma
  • t(11;18)
    • MALT lymphoma - associated with antibiotic resistance in gastric MALT
  • t(11;22)(q24;q11.2-12)
  • t(12;16)
  • t(14;18) (q32;q21)
    • Bcl-2 (18) is translocated next to the immunoglobulin heavy chain locus. See Apoptosis for further discussion of Bcl-2
    • Follicular lymphoma 80-90%
    • DLBCL ~30%
  • t(15;17)
    • Acute promyelocytic leukemia
  • t(17;22):
  • t(21;22)
  • t(X;18)(p11.2;q11.2)