Radiation Oncology/Cancer genetics
From Wikibooks, the open-content textbooks collection
< Radiation Oncology(Redirected from Radiation Oncology/List of Chromosomes and their related cancer genes)
|
[edit]
Chromosome 1
Chromosome 2
Chromosome 3
- 3p26: Von-Hippel Lindau, VHL gene (3p26)
Chromosome 4
Chromosome 5
- 5q deletion: Familial Adenomatous Polyposis (FAP) Syndrome and Hereditary Colorectal Syndromes
Chromosome 6
Chromosome 7
Chromosome 8
Chromosome 9
- 9q34.1: Abl, involved in bcr-abl fusion gene
Chromosome 10
Chromosome 11
Chromosome 12
Chromosome 13
Chromosome 14
Chromosome 15
Chromosome 16
Chromosome 17
Chromosome 18
- 18q21.3: Bcl-2 gene, follicular lymphoma, t(14;18)(q32;q21)
Chromosome 19
Chromosome 20
Chromosome 21
Chromosome 22
- 22q11.2: Bcr gene, bcr-abl translocation (Philadelphia chromosome), CML
Chromosome X
Chromosome Y
[edit] Chromosomal translocations involved in oncology
- See also List of chromosomal translocations at Wikipedia
- t(1;12)(q21;p13) - Acute myelogenous leukemia
- t(2;5)(p23;q35) - anaplastic large cell lymphoma
- t(8;14)
- c-myc
- Burkitt's lymphoma
- t(9;12)(p24;p13) CML, ALL
- t(9;22)(q34;q11), Philadelphia chromosome
- BCR / ABL fusion gene. Role of BCR is not completely clear, but appears to be involved with superoxide production. Abl has 2 isoforms: nuclear abl is involved with regulation of cell death after DNA damage. Cytoplasmic abl appears to function in cell adhesion
- Results in CML, ALL
- t(11;14)
- Mantle cell lymphoma
- t(11;18)
- MALT lymphoma - associated with antibiotic resistance in gastric MALT
- t(11;22)(q24;q11.2-12)
- Ewing's sarcoma
- t(14;18) (q32;q21)
- Bcl-2 (18) is translocated next to the immunoglobulin heavy chain locus. See Apoptosis for further discussion of Bcl-2
- Follicular lymphoma 80-90%
- DLBCL ~30%
- t(15;17) - Acute promyelocytic leukemia
- t(17;22) - Dermatofibrosarcoma protuberans
- t(X;18)(p11.2;q11.2) - Synovial sarcoma
