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< Radiation Oncology | Sarcoma(Redirected from Radiation Oncology/Miscellaneous/Hemangiopericytoma)
- Malignant vascular tumor
- Tumor cells appear like smooth muscle cells, but don't arise from endothelial cells
- Cell of origin not clear, possibly derived from pericytes
- Most commonly in pelvic, proximal femur, humerus, and vertebral bodies
- Median age in 4th and 5th decade
- Typically slow growing
- Radiography not definitive
- Easily confused with meningioma. No calcifications or hyperostosis on CT (where as meningiomas have these features)
- larger lesions will show flow voids on MRI.
- Treatment frequently surgical, role of chemo and RT not clear, although small series show lower rates of recurrence with addition of radiotherapy.
- Heidelberg, 2005 (Germany) (1984-2004) PMID 16222690 — "Precision radiotherapy for hemangiopericytomas of the central nervous system." (Combs SE et al. Cancer. 2005 Dec 1;104(11):2457-65.)
- Retrospective. 25 patients. 23 surgical resection. Treated with fractionated stereotactic RT or IMRT for tumors of the CNS and spine. Median dose 54 (in 1.8-2 Gy/fx)
- OS: 5-years 100%, 10-years 64%. 5-year PFS 61%
- Conclusion: "High precision" RT effective and safe