Radiation Oncology/Toxicity/Bone marrow
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- Also please see Toxicity/Pelvis
See also: Radiation Oncology/IMRT/Pelvis
Bone marrow distribution[edit | edit source]
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Distribution of Bone Marrow
- 1961: (London) - PMID 13726497 — "The distribution of active bone marrow in the adult." Ellis RE et al. Phys Med Biol. 1961 Jan;5:255-8.
- By weighing cadaveric bones.
| Site | % Total red marrow |
| Pelvis (made up of) |
40.0 |
Pelvic bones |
22.3 |
Sacrum |
13.9 |
Femoral head/neck |
3.8 |
| Thoracic spine | 14.1 |
| Lumbar spine | 10.9 |
| Head | 13.1 |
| Upper Limb Girdle (made up of) |
8.3 |
Scapulae |
4.8 |
Humeri |
1.9 |
Clavicles |
1.5 |
| Ribs | 7.9 |
| Cervical spine | 3.4 |
| Sternum | 2.3 |
Cervical Cancer[edit | edit source]
- UC San Diego
- 2011 PMID 20400238 -- "Normal tissue complication probability modeling of acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy." (Rose BS, Int J Radiat Oncol Biol Phys. 2011 Mar 1;79(3):800-7. Epub 2010 Apr 17.)
- Retrospective. 81 patients treated with concurrent chemo-RT for cervical cancer. DVHs of bone marrow in pelvic field evaluated
- Outcome: V10 <95% and V20 <76% correlated with lower acute G3+ hematologic toxicity. V10 (25% vs 69%, SS) and V20 (22% vs 58%, SS)
- Conclusion: Acute hematologic toxicity increases with increasing pelvic bone marrow volume irradiated
- 2011 PMID 20400238 -- "Normal tissue complication probability modeling of acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy." (Rose BS, Int J Radiat Oncol Biol Phys. 2011 Mar 1;79(3):800-7. Epub 2010 Apr 17.)