Radiation Oncology/NSCLC/RTOG Lung

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NSCLC: RTOG OPEN TRIALS
Number Title
09-15 A Randomized Phase II Study Comparing 2 Stereotactic Body Radiation Therapy (SBRT) Schedules For Medically Inoperable Patients With Stage I Peripheral Non-Small Cell Lung Cancer
08-13 Seamless Phase I/II Study of Stereotactic Lung Radiotherapy (SBRT) For Early Stage, Centrally Located, Non-Small Cell Lung Cancer (NSCLC) In Medically Inoperable Patients
06-18 A Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) in the Treatment of Patients with Operable Stage I/II Non-Small Cell Lung Cancer
06-17 A Randomized Phase III Comparison of Standard-Dose (60 Gy) Versus High Dose (74 Gy) Conformal Radiotherapy With Concurrent and Consolidation Carboplatin/Paclitaxel +/- Cetuximab (IND #103444) In Patients With Stage IIIA/IIIB Non-Small Cell Lung Cancer
02-29 A Phase II Trial Of Neoadjuvant Therapy With Concurrent Chemotherapy And High Dose Radiotherapy Followed by Surgical Resection And Consolidative Therapy For Locally Advanced Non-Small Cell Lung Carcinoma


NSCLC: RTOG CLOSED TRIALS
Number Title Publication
PMID XXXXXXXXXX
05-15 A Comparative Study Of Gross Tumor Volume Definition With Or Without PET Fusion For Patients With Non-Small Cell Lung Carcinoma
04-12 SWOG S0332
Phase III Randomized Trial of Preoperative Chemotherapy Versus Preoperative Concurrent Chemotherapy and Thoracic Radiotherapy Followed by Surgical Resection and Consolidation Chemotherapy in Favorable Prognosis Patients with Stage IIIA (N2) Non-Small Cell Lung Cancer
CLOSED - POOR ACCRUAL
03-24 A Phase II Study Of Cetuximab (C225) In Combination With Chemoradiation In Patients With Stage IIIA/B Non-Small Cell Lung Cancer (NSCLC) chapter link
PMID 21555682
02-36 A Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) in the Treatment of Patients with Medically Inoperable Stage I/II Non-Small Cell Lung Cancer
02-35 Positron Emission Tomography Pre- and Post-treatment Assessment for Locally Advanced Non-small Cell Lung Carcinoma
02-14 A Phase III Comparison Of Prophylactic Cranial Irradiation Versus Observation In Patients With Locally Advanced Non-Small Cell Lung Cancer
02-13 A Phase I/II Trial of A Cox-2 Inhibitor, Celebrex (Celecoxib), with Limited Field Radiation for Intermediate Prognosis Patients with Locally Advanced Non-Small Cell Lung Cancer, with Analysis of Prognostic Factors
CLOSED - ACCRUAL NOT MET
01-17
01-17
A Phase I/II Dose Intensification Study using Three Dimensional Conformal Radiation Therapy and Concurrent Chemotherapy for Patients with Inoperable, Non-Small Cell Lung Cancer PMID 20368547
PMID 20457350
00-17 Clinicaltrials.gov A Phase I Study Of Gemcitabine, Carboplatin Or Gemcitabine, Paclitaxel And Radiation Therapy Followed By Adjuvant Chemotherapy For Patients With Favorable Prognosis Inoperable Stage IIIA/B Non-Small Cell Lung Cancer (NSCLC) PMID 19096311
00-15 Clinicaltrials.gov SWOG S9900
A Randomized Phase III Trial Surgery Alone or Surgery Plus Preoperative Paclitaxel/Carboplatin in Clinical Stage IB (T2N0), II (T1-2N1, T3N0) and Selected IIIA (T3N1) Non Small Cell Lung Cancer (NSCLC)
PMID 20231678
99-09 Phase II Study of Postoperative Adjuvant Immunotherapy and Radiation in Patients with Completely Resected Stage II and Stage IIIA Non-Small Cell Lung Cancer
98-01 Clinicaltrials.gov A Phase III Study Of Amifostine Mucosal Protection For Patients With Favorable Prognosis Inoperable Stage II-IIIA/B Non-Small Cell Lung Cancer (NSCLC) Receiving Sequential Induction And Concurrent Hyperfractionated Radiotherapy With Paclitaxel And Carboplatin PMID 15800308
PMID 18501528
PMID 19858383
97-05 Phase II Study of Postoperative Adjuvant Therapy in Patients With Completely Resected Stage II and Stage IIIA Non-Small Cell Lung Cancer PMID 15908657
97-01 Phase III Randomized Trial of Radiation Therapy Alone versus Concurrent Chemotherapy plus Radiation Therapy for Poor-Risk Stage III Non-Small-Cell Lung Carcinoma
CLOSED - POOR ACCRUAL
96-16 CALGB 9633
A Phase III Study of Adjuvant Chemotherapy After Resection for Patients with T2N0 Stage I Non-small Cell Carcinoma of the Lung
PMID 18809614
95-11 CALGB 9334, Intergroup
Sclerois of Pleural Effusions by Talc Thoracoscopy Versus Talc Slurry: A Phase III Study
94-10
94-10
A Three-Arm Phase III Study of Concomitant Versus Sequential Chemotherapy and Thoracic Radiotherapy for Patients with Locally Advanced Inoperable Non-Small Cell Lung Cancer ASCO 2003
94-09 ECOG ECOG E4592
LABORATORY/CLINICAL CORRELATIVE STUDIES IN NON-SMALL CELL LUNG CANCER. ANCILLARY STUDY TO RTOG 91-05/INT 0115
93-11
93-11
A Phase I-II Dose Escalation Study in Patients with Inoperable Non-Small Cell Lung Cancer PMID 15667949
93-09
93-09
INT 0139
A Phase III Comparison Between Concurrent Chemotherapy Plus Radiotherapy, and Concurrent Chemotherapy plus Radiotherapy followed by Surgical Resection for Stage IIIA (N2) Non-Small Cell Lung Cancer
PMID 19632716
92-04 PMID 12062596
91-06
Clinicaltrials.gov
Phase I/II Study of Chemotherapy with CDDP/Oral VP-16 plus Radiotherapy in Patients with Locally Advanced, Inoperable non-Small Cell Lung Cancer PMID 8648357
91-05
91-05
INT 0115, ECOG E3590
Randomized Trial of Postoperative Adjuvant Therapy in Patients with Completely Resected Stages II and IIIa Non-Small Cell Lung Cancer
PMID 11071672
91-03 PULMONARY FUNCTION OF PATIENTS WITH RADIATION THERAPY FOR NON-SMALL LUNG CANCER
89-01 Phase III study comparing chemotherapy and radiotherapy with preoperative chemotherapy and surgical resection in patients with non-small-cell lung cancer with spread to mediastinal lymph nodes (N2) PMID 12243809


See also:

  • PMID 7635796 (1995) — "The evolution of Radiation Therapy Oncology Group (RTOG) protocols for nonsmall cell lung cancer." Byhardt RW et al. Int J Radiat Oncol Biol Phys. 1995 Jul 30;32(5):1513-25.