Radiation Oncology/Lymphoid

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Hematologic Malignancies

Chapter Links[edit]

Indications

Technique

Conceptual Simplified Classification[edit]

Lymphoid Disorders[edit]

Myeloid Disorders[edit]

  • Acute myeloid leukemia (AML)
  • Chronic myeloid disorders
    • Myeloproliferative disease (MPD)
      • Chronic myelogenous leukemia (CML)
      • Polycythemia vera
      • Essential thrombocythemia
    • Myelodysplastic/myeloproliferative diseases
    • Myelodysplastic syndromes (MDS)


WHO classification[edit]

Myeloid Neoplasms[edit]

  • Acute myeloid leukemia (AML)
  • Acute biphenotypic leukemias
  • Myeloproliferative disease
    • Chronic myelogenous leukemia (CML)
    • Chronic neutrophilic leukemia
    • Chronic eosinophilic leukemia/hypereosinophilic syndrome
    • Chronic idiopathic myelofibrosis
    • Polycythemia vera
    • Essential thrombocythemia
    • Myeloproliferative disease, unclassifiable
  • Myelodysplastic/myeloproliferative diseases
    • Chronic myelomonocytic leukemia
    • Atypical chronic myelogenous leukemia
    • Juvenile myelomonocytic leukemia
  • Myelodysplastic syndromes (MDS)
    • Refractory anemia
    • With ringed sideroblasts
    • Without ringed sideroblasts
    • Refractory cytopenia
    • Refractory anemia
    • 5q- (5q deletion) syndrome
    • Myelodysplastic syndrome, unclassifiable

Lymphoid: B-cell neoplasms[edit]

Lymphoid: T-cell and NK-cell neoplasms[edit]

Lymphoid: Hodgkin Lymphoma[edit]

  • Nodular lymphocyte-predominant Hodgkin lymphoma
  • Classical Hodgkin lymphoma
    • Nodular sclerosis Hodgkin lymphoma (grades 1 and 2)
    • Lymphocyte-rich classical Hodgkin lymphoma
    • Mixed cellularity Hodgkin lymphoma
    • Lymphocyte depletion Hodgkin lymphoma

Lymphoid: Posttransplant Lymphoproliferative Disorders[edit]

  • Early lesions
    • Reactive plasmacytic hyperplasia
    • Infectious mononucleosis-like
  • PTLD polymorphic
    • Polyclonal (rare)
    • Monoclonal
  • PTLD monomorphic (classify according to lymphoma classification)
    • B-cell lymphomas
    • T-cell lymphomas
  • Other types (rare)

Mast Cell Disorders[edit]

  • Cutaneous mastocytosis
  • Systemic mast cell disease (+/- skin involvement)
  • Systemic mast cell disease with associated hematologic disorder (+/- skin involvement)
  • Mast cell leukemia/sarcoma

Histiocytic and Dendritic Cell Neoplasms[edit]

  • Macrophage/Histiocytic neoplasm
    • Histiocytic sarcoma
  • Dendritic-cell neoplasms
    • Langerhans cell histiocytosis
    • Langerhans cell sarcoma
    • Interdigitating dendritic cell sarcoma/tumor
    • Follicular dendritic cell sarcoma/tumor
    • Dendritic cell sarcoma, not otherwise specified