Radiation Oncology/SCLC/Extensive Stage

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Front Page: Radiation Oncology \| RTOG Trials \| Randomized Trials	Edit this
SCLC: Main Page \| Overview \| Anatomy \| Limited Stage \| Extensive Stage \| PCI \| Randomized

Extensive Stage Small Cell Lung Cancer

[edit] Consolidation Thoracic Radiotherapy

Kragujevac, Yugoslavia (1988-1993) -- Consolidation RT vs consolidation cisplatin/etoposide
- Randomized. 210 patients treated w/ 3 cycles of cisplatin/etoposide (PE). Pts w/ distant-CR + local-CR/PR randomized to RT (54 Gy in 36 fx over 18 days) with concurrent carboplatin/etoposide followed by 2 more cycles of PE vs 4 additional cycles of PE.
- 1999 PMID 10561263 "Role of radiation therapy in the combined-modality treatment of patients with extensive disease small-cell lung cancer: A randomized study." (Jeremic B et al. J Clin Oncol. 1999 Jul;17(7):2092-9.)
  - Outcome: Median OS RT 17 months vs chemo 11 months (SS); 5-year OS 9% vs 4%. No difference in DMFS.
  - Conclusion: Patients with good response to initial chemo may have improved overall survival with consolidative RT