Radiation Oncology/CNS/RTOG Brain

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Brain/CNS: RTOG OPEN TRIALS
Number Site Title
08-37 GBM Randomized, Phase II, Double-Blind, Placebo-Controlled Trial of Conventional Chemoradiation and Adjuvant Temozolomide Plus Cediranib Versus Conventional Chemoradiation and Adjuvant Temozolomide Plus Placebo in Patients With Newly Diagnosed Glioblastoma
08-34 Anaplastic Glioma Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma: The CATNON Intergroup Trial
08-25 GBM PHASE III DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF CONVENTIONAL CONCURRENT CHEMORADIATION AND ADJUVANT TEMOZOLOMIDE PLUS BEVACIZUMAB VERSUS CONVENTIONAL CONCURRENT CHEMORADIATION AND ADJUVANT TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA
06-27 GBM (recur.) Phase II Trial of Dasatinib in Patients With Recurrent Glioblastoma Multiforme
06-25 GBM (recur.) A RANDOMIZED PHASE II TRIAL OF BEVACIZUMAB WITH IRINOTECAN OR BEVACIZUMAB WITH TEMOZOLOMIDE IN RECURRENT GLIOBLASTOMA
06-14 WBRT A Randomized, Phase III, Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy
06-11 GBM Urinary VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence
05-39 Meningioma Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas
05-25 GBM Phase III Trial Comparing Conventional Adjuvant Temozolomide With Dose-Intensive Temozolomide in Patients With Newly Diagnosed Glioblastoma
03-20 Cancer.gov Mets A PHASE III TRIAL COMPARING WHOLE BRAIN RADIATION AND STEREOTACTIC RADIOSURGERY ALONE VERSUS WITH TEMOZOLOMIDE OR ERLOTINIB IN PATIENTS WITH NON-SMALL LUNG CANCER AND 1-3 BRAIN METASTASES
02-27 Cancer.gov PCNSL Phase I/II Study of Pre-Irradiation Chemotherapy With Methotrexate, Rituximab, and Temozolomide and Post-Irradiation Temozolomide for Primary Central Nervous System Lymphoma
98-13 Cancer.gov AA and AOA A Phase I/III Randomized Study Of Radiation Therapy And Temozolomide (IND #60,265) Versus Radiation Therapy And Nitrosourea For Anaplastic Astrocytoma and Mixed Anaplastic Oligoastrocytoma (Astrocytoma Dominant) PMID 15234047 (phase I)
98-06 GBM A Phase II Study of Conventional Radiation Therapy Plus Thalidomide For Supratentorial Glioblastoma


Brain/CNS: RTOG CLOSED TRIALS
Number Site Title Publication
05-13 Cancer.gov GBM A Phase I/II Trial of Temozolomide, Motexafin Gadolinium, and 60 Gy Fractionated Radiation for Newly Diagnosed Supratentorial Glioblastoma Multiforme Closed 7/1/2009
04-24 Cancer.gov LGG A Phase II Study of Temozolomide-Based Chemoradiotherapy Regimen for High Risk Low-Grade Gliomas Closed 10/31/2009
04-20 Cancer.gov GBM A PHASE II STUDY OF RADIATION THERAPY PLUS LOW DOSE TEMOZOLOMIDE FOLLOWED BY TEMOZOLOMIDE PLUS IRINOTECAN FOR GLIOBLASTOMA MULTIFORME ASCO 2006
02-11 Cancer.gov GBM A PHASE I/II STUDY OF AN ORAL EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR (EGFR-TKI), ZD 1839 (IRESSA), [NSC# 715055] WITH RADIATION THERAPY IN GLIOBLASTOMA MULTIFORME ASCO 2004
ASCO 2006
01-31 Clinicaltrials.gov Glioma: AO and Mixed AOA A Phase II Trial of Pre-Irradiation and Concurrent Temozolomide in Patients with Newly Diagnosed Anaplastic Oligodendrogliomas and Mixed Anaplastic Oligoastrocytomas PMID 18779504
01-18 Clinicaltrials.gov Mets A Phase III Study of Conventional Radiation Therapy Plus Thalidomide (NSC# 66847) Versus Conventional Radiation Therapy for Multiple Brain Metastases PMID 18164847
PMID 18164829
00-23 Clinicaltrials.gov GBM A Phase II Trial of Accelerated Radiotherapy Using Weekly Stereotactic Conformal Boosts For Supratentorial Glioblastoma Multiforme PMID 16750317
00-21 GBM A Phase II Trial Of Conventional Radiation Therapy Plus High Dose Tamoxifen For The Treatment Of Supratentorial Glioblastoma Multiforme PMID 16443947
98-13 AA PMID 15234047
98-06 Glioma [Phase II, RT + Thalidomide]
98-03 GBM Phase I/II Radiation Dose Escalation Study Applying Conformal Radiation Therapy In Supratentorial Glioblastoma Multiforme PMID 19533025 (QOL)
PMID 18723297
98-02 Clinicaltrials.gov LGG A Phase II Study of Observation in Favorable Low-Grade Glioma and a Phase III Study of Radiation With or Without PCV Chemotherapy in Unfavorable Low-Grade Glioma PMID 18976072
97-10 GBM A phase II study of conventional radiation therapy followed with recombinant interferon beta for supratentorial glioblastoma ASTRO 2001
PMID 16887285
96-02 Glioma [Phase II, RT + Taxol]
95-08 Cancer.gov Mets A PHASE III TRIAL COMPARING WHOLE BRAIN IRRADIATION WITH VERSUS WITHOUT STEREOTACTIC RADIOSURGERY BOOST FOR PATIENTS WITH ONE TO THREE UNRESECTED BRAIN METASTASES PMID 15158627
95-07 GBM Phase I Study of Topotecan plus Cranial Radiotherapy for Glioblastoma Multiforme PMID 11181676
94-04 AA PMID 15001257
94-02 Clinicaltrials.gov AO Phase III intergroup randomized comparison of radiation alone vs pre-radiation chemotherapy for pure and mixed anaplastic oligodendrogliomas PMID 11586105
PMID 16782910
PMID 18371182
PMID 19783377 (QOL)
93-10 PCNSL PMID 16193393
93-05 Glioma [+/- SRS then RT + BCNU]
91-13 HGG (Recur.) PMID 9210068
91-10 LGG A phase III evaluation of postoperative radiation in low grade intracranial astrocytomas and oligodendrogliomas PMID 11980997
PMID 12829670 (Cognitive)
PMID 15964709 (Cognitive)
90-06 Glioma [BCNU + (HF-RT vs RT)]
90-05 Mets [Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases] PMID 8621289
PMID 10802351
85-28 Mets [Phase I/II trial of accelerated fractionation in brain metastases] PMID 8330997
PMID 8435812
84-09 Glioma [Phase I/II WBRT + AZQ]
83-02 HGG [Phase I/II trial of hyperfractionated and accelerated hyperfractionated radiation therapy with carmustine for adults with supratentorial malignant gliomas] PMID 1451073
PMID 8380567
PMID 8608540 more..
79-18 Glioma [WBRT + (BCNU vs Misonidazole + BCNU)]
74-01 HGG [WBRT 60 Gy vs 60 Gy + 10 Gy boost vs 60 Gy + BCNU vs 60 Gy + BCNU + dacarbazine] PMID 3281031

Note: Titles are given in brackets when the official protocol title is not known