Radiation Oncology/Corporate/Protons

Proton Therapy

• Please see the Protons page for links to clinical information

Associations

• Particle Therapy Cooperative Group (PTCOG)
  • "An organization for those interested in proton, light ion, and heavy charged particle radiotherapy"

• National Association for Proton Therapy (NAPT)
  • U.S. based, independent, non-profit, public benefit corporation
  • Promotes the clinical benefits of proton beam radiation therapy for cancer patients and their families

Existing Proton Facilities

North America

• Canada
  • TRIUMF - ocular diseases only
• United States
  • Loma Linda
  • Harvard University (Massachusetts General Hospital)
  • Midwest Proton Radiotherapy Institute
  • MD Anderson Cancer Center
  • University of California San Francisco/University of California Davis - ocular diseases only
  • University of Florida
  • ProCure Oklahoma
  • University of Pennsylvania
  • Hampton University, VA
  • CDH Proton Center ProCure, IL

Europe

• Belgium
  • Louvain
• France
  • Centre Antoine Lacassagne (Nice)
  • Institut Curie (Orsay)
• Germany
  • Hahn-Meitner Institut (HMI/Charite) - ocular diseases only
  • Rinecker PTC
  • Heidelberg HIT
• Italy
  • Catana - ocular diseases only
  • CNAO
• Russia
  • Institute of Theoretical and Experimental Physics (ITEP, Moscow)
  • Joint Institute for Nuclear Research (JINR, Dubna), YouTube link
  • Petersburg Nuclear Physics Institute (PNPI)
• Sweden
  • Uppsala Universitet
• Switzerland
  • Paul Scherrer Institut (PSI)
• United Kingdom
  • Clatterbridge Center for Oncology - ocular diseases only

Asia

• China
  • Wanjie Proton Therapy Center
• Japan
  • National Cancer Center Hospital East
  • Kobe Univeristy (Hyogo Medical Center)
  • National Institute of Radiological Sciences, Chiba
  • Shizuoka Cancer Center
  • University of Tsukuba
  • Southern Tohoku Proton Therapy Cancer Center, Fukushima
  • Wakasa Bay
• Korea
  • Korea National Cancer Center

Africa

• South Africa
  • IThemba LABS, South Afrcia

Chronologic List Overview

Facility	Country	Start	Particle	Comments
Lawrence Berkeley Laboratory	USA	1955	Proton, Heavy Ion
Svedberg Laboratory	Sweden	1957	Proton	New facility Uppsala, 1988
Harvard Cyclotron	USA	1961	Proton	New facility in 2001
JINR	Russia	1964	Proton	New facility 1989
ITEP	Russia	1969	Proton
PNPI	Russia	1975	Proton
Chiba	Japan	1979	Proton
Tsukuba	Japan	1983	Proton
PSI	Switzerland	1984	Proton
JINR	Russia	1989	Proton
Uppsala	Sweden	1989	Proton
Clatterbridge	UK	1989	Proton	ocular only
Loma Linda	USA	1990	Proton	first hospital-based
Nice	France	1991	Proton
Orsay	France	1991	Proton
LOuvain	Belgium	1991	Proton	low energy only
iTHEMBA	South Africa	1993	Proton
MPRI	USA	1993	Proton
UCSF / UC Davis	USA	1994	Proton	ocular only
Chiba	Japan	1994	Carbon	first ion
TRIUMF	Canada	1995	Proton	ocular only
GSI	Germany	1997	Carbon
HMI	Germany	1998	Proton	ocular only
NCC	Japan	1998	Proton
Hyogo	Japan	2001	Proton, Carbon
Harvard	USA	2001	Proton
Catana	Italy	2002	Proton	ocular only
Shizuoka	Japan	2002	Proton
Wakasa	Japan	2002	Proton
Wanjie	China	2004	Proton
MD Anderson	USA	2006	Proton
University of Florida	USA	2006	Proton
Southern Tohoku PTC	Japan	2008	Proton
Rinecker PTC	Germany	2009	Proton
Oklahoma ProCure	USA	2009	Proton
Heidelberg HIT	Germany	2009	Proton/Carbon
University of Pennsylvania	USA	2010	Proton
Hampton University	USA	2010	Proton
CDH ProCure Chicago	USA	2010	Proton
CNAO	Italy	2011	Proton/(Carbon)

Proposed Proton Facilities

United States

• Northern Illinois University, IL
• ProCure
  • ProCure: CentraState Health, NJ - IBA - target 2012
  • ProCure: Beaumont Hospital, MI
  • ProCure: Boca Raton, FL
  • ProCure: Seattle Cancer Care Alliance: Seattle, WA
• American Shared Hospital Services
  • American Shared Hospital Services: Tufts University, MA
  • American Shared Hospital Services: MD Andersen Orlando, FL
  • American Shared Hospital Services: Long Beach Memorial, CA
  • American Shared Hospital Services: San Francisco Bay area, CA
  • American Shared Hospital Services: Kettering Medical Center, Dayton, OH
• Lehigh Valley Hospital, PA
• South Florida Proton Center, FL
• Broward Medical Center, FL
• Washington University, MO
• First Coast Oncology, FL
• McLaren Health Care, MI - ProTom
• Dayton, OH - Optivus
• University of Iowa, IA
• Scripps Health, CA - Varian
• Wright State University, OH
• Knoxville, TN
• University of Maryland, MD
• Mayo Clinics, MN and AZ
• Emory University, GA
• Atlantic Health System, NJ - ProTom
• Texas Oncology, Dallas, TX
• Willis-Knighton, Shreveport, LA (Summer 2014)

Europe

• MedAustron, Austria - proton and carbon ion
  • Abstract 2007
• WPE Essen, Germany
• Prague, Czech Republic
• Rozumberok, Slovakia
• Krakow, Poland
• Caen, France - carbon ion
• Dimitrovgrad, Russia

Middle East

• Qatar

Asia

• National Taiwan University Hospital, Taiwan
• Linkou Chang Gung Hospital, Taiwan
• Shanghai Proton and Heavy Ion Hospital

Vendors

• Hitachi and Hitachi North America
  • Proton facilities: Tsukuba, MD Anderson
• IBA
  • Proton facilities: Massachusetts General Hospital, National Cancer Center Japan, National Cancer Center Korea, Wanjie Proton Therapy Center, Midwest Proton Radiotherapy Institute
• Optivus Proton Therapy
  • Proton facilities: Loma Linda
• Varian Medical Systems (ACCEL subsidiary)
  • Proton facilities: Paul Scherrer Institute
• Siemens AG
• Still River Systems
• ProTom International
• Compact Particle Acceleration Corporation & TomoTherapy

Treatment Planning

• PerMedics Medical Systems - Odyssey
• Elekta via CMS software - XiO and Focal

Patient Positioning

• Brindisi, Italy; 2010 PMID 20465816 -- "Patient positioning in the proton radiotherapy era." (Devicienti S, J Exp Clin Cancer Res. 2010 May 13;29(1):47. [Epub ahead of print])
  • Review of various robotic couch applications

Overview by Institution

• Heidelberg, Germany; 2010 PMID 20831505 -- "Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patients." (Combs SE, Acta Oncol. 2010 Oct;49(7):1132-40.)

• CNAO Italy; 2009 PMID 19579862 -- "The National Center for Oncological Hadron Therapy: status of the project and future clinical use of the facility." (Orecchia R, Tumori. 2009 Mar-Apr;95(2):169-76.)
  • Overview of plans for the facility

• Hyogo Japan; 2009 PMID 19920379 -- "[Current status and future of particle radiotherapy at the Hyogo Ion Beam Medical Center]" [Article in Japanese] (Murakami M, Gan To Kagaku Ryoho. 2009 Nov;36(11):1791-4.)
  • Overview. 2,639 patients treated with prostate, H&N, liver, lung and sarcomas (total 87%). Proton beam 2,122 (80%), carbon ion 517 (20%)

• European ENLIGHT network
  • 2008 PMID 18208851 -- "COST-ENLIGHT strategic workshop on hadron (particle) therapy, CERN, Geneva, 3-4 May 2007." (Taylor RE, Br J Radiol. 2008 Mar;81(963):169-71. Epub 2008 Jan 21.)
    • Overview of meeting to review current status of hadron therapy in Europe
  • 2007 PMID 17513898 -- "European developments in radiotherapy with beams of large radiobiological effectiveness." (Amaldi U, J Radiat Res (Tokyo). 2007;48 Suppl A:A27-41.)
    • Overview of European experience, including development of facilities in Heidelberg (HIT) and Pavia (CNAO). Also review of Marburg, Wiener Neustadt, Lyon and Uppsala and the development of ENLIGHT network

• Paul Scherrer Institut; 2007 PMID 17878101 -- "[Proton beam therapy: clinical indications and summary of the Swiss experience] - [Article in French]" (Weber DC, Bull Cancer. 2007 Sep 1;94(9):807-15.)

• Harvard
  • 2007 PMID 17668954 -- "Clinical proton radiation therapy research at the Francis H. Burr Proton Therapy Center." (DeLaney TF, Technol Cancer Res Treat. 2007 Aug;6(4 Suppl):61-6.)
    • Review of MGH current clinical research goals
  • 1980 PMID 6245096 -- "Clinical experience with proton beam radiation therapy." (Suit HD, J Can Assoc Radiol. 1980 Mar;31(1):35-9.)
    • Cannot yet assess efficacy, but results warrant further investigation

• Loma Linda; 2007
  • 2007 PMID 17668955 -- "Development and operation of the Loma Linda University Medical Center proton facility." (Slater JD, Technol Cancer Res Treat. 2007 Aug;6(4 Suppl):67-72.)
    • Overview of a hospital-based center development
  • 2006 PMID 16551128 -- "Clinical applications of proton radiation treatment at Loma Linda University: review of a fifteen-year experience." (Slater JD, Technol Cancer Res Treat. 2006 Apr;5(2):81-9.)
    • Review of 15 year experience using protons

Other Entities

• GSI, Germany
• ProBeam Oncology, USA
  • Partnership between MD Anderson Cancer Center, Sanders Morris Harris, and The Styles Company to manage the Proton Therapy Center at MD Anderson
• Proton Brotherhood of the Balloon, USA
• ProCure Treatment Centers, USA
• TERA Foundation, Italy
• Proton Therapy Global Management
• SAH Global