Chemical Sciences: A Manual for CSIR-UGC National Eligibility Test for Lectureship and JRF/Named Reactions/Barton Reaction

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The Barton Reaction involves the photolysis of a nitrite to form a δ-nitroso alcohol. It is named for the British chemist Sir Derek Harold Richard Barton.[1] The mechanism is believed to involve a homolytic RO–NO cleavage, followed by δ-hydrogen abstraction and free radical recombination.[2]

Barton reaction

A related reaction is the Hofmann-Löffor-Freytage reaction involving haloamines.

References[edit]

  1. doi:10.1021/ja01480a030
  2. IUPAC Goldbook